What is MAK  The extract from the cultured solid medium of Ganoderma lucidum mycelia.Since 1996.

- Nutrient-rich MAK

“MAK” is the extract from the cultured solid medium of mannentake (Ganoderma lucidum), which has been valued as a “Jo” (meaning superior) on Kampo medicine category or Shen [meaning God with Chinese] tonic at China since ancient times. MAK is produced by basically the same method of LEM (the extract from the cultured solid medium of Lentinus edodes). All ingredients of MAK are produced by the power of nature, because these nutritions were obtained from metabolic productions by the digestion of plant cell walls with its own enzymes from mycelia and from the degradation products by autolysis of mycelia, during on the growth of mannentake mycelia on the solid medium consisting of bagasse (fibers after collecting sugar from sugarcane) and rice bran.  
MAK has the ability of protective effect against encephalopathy, inhibition of blood pressure elevation, inhibition of blood sugar elevation, antioxidation, immunopotentiation and antiviral action, etc.



Reishi was mentioned in a Chinese herbal published approximately 3000 years ago, Shen Nung Pen Tsao Ching, as top-quality (the most excellent grade of the  quality among three ranks) which caused no adverse effect by intake for a long time and was described as if one continuously eats it for a long time, it will make him/her stay young and promote longevity to become a holy man.In the era when the fungus could not be artificially grown, it was quite rare and prized as a golden remedy for immortality.The known beneficial effects of Reishi include anti-cancer effect, hypotensive effect, anti-oxidation, anti-thrombogenesis, blood sugar-lowering effect, antiallergic activity, prevention of arteriosclerosis, decline of fever, anti -inflammation,  hardiness and treatment for hepatitis.  

- Physiological effects of MAK which have been already confirmed


  1. Adjuvanticity:  

MAK activates macrophages which function as a control tower in the immune system. In addition, it shows a modulating effect for the immune system by enhancing production of cytokines such as IL-1, IL-2,IL-12 and INF-γ.

  1. Antitumor effect:

MAK inhibits a precancerous state induced by carcinogens and supresses the growth of tumors formed. It also inhibits the growth of cancer cells.

  1. Antioxidative effect:

MAK eliminates radicals that are active oxygen, showing SOD-like activities. It also inhibits the formation of lipid peroxide to reduce active oxygen in the body.

  1. Antivirus effect:

MAK mitigates hepatocellular injury in patients with hepatitis C and inhibits infection with herpesvirus.

  1. Hepatocyte protection:

MAK protects liver cells.

  1. Radioprotection:

MAK has a protective effect on tissues from injury by radiation.

  1. Inhibition of blood pressure elevation:

MAK inhibits an increase in blood pressure without influence on normal blood pressure.

  1. Inhibition of an increase in blood sugar level:

MAK inhibits an increase in blood sugar level after eating by inhibiting an activity of enzymes which degrade carbohydrates. In addition, it has an effect to promote insulin secretion.

  1. Protection against neuronal damage:

MAK prevents brain injury caused by ischemia/ reperfusion.

  1. Prevention against ulcerative colitis:

MAK has an anti-inflammatory effect, resulting in prevention of ulcerative colitis.

  1. Mitigation of adverse effects by anticancer drugs:

MAK reduces toxicity in the digestive tracts and testis caused by anticancer drugs.

Evidence of the power of “MAK”  
- Active components of MAK -  

Useful substances in MAK include lignin and polysaccharides, which are soluble at low molecular weights, as well as complexes of these proteins and sugars; β-glucan derived from Ganoderma lucidum; and terpenes.
These substances are different from the products extracted from the bodies of mushrooms or liquid cultures of mycelium. 


What is the function of MAK?

Since MAK is an immune modulator, it is mainly used by people with reduced immunosensitivity. A patient undergoing conventional cancer treatment. For this reason, MAK is commonly used in clinics and facilities as part of an integrated or complementary approach, along with traditional treatments.
It has been confirmed that MAK has numerous effects, including protection against encephalopathy, reduction of elevated blood pressure, reduction of elevated blood sugar, anti-oxidation, immunological enhancement, and an antiviral effect.
Where is MAK Made?

While products containing MAK are sold all around the world, the raw material used in their production is made nowhere else but our factory.



Safety and reliability of “MAK”
- Safety of MAK -

Since ancient times, mannentake has been relied on by people for no side effects even if taken long time. the safety of MAK has been proved on various safety test (e.g. toxicity and mutagenicity tests) by specialized institutions.

Acute toxicity Rats(male)
The limited test nlt 22,500 mg/kg
2,000 mg/kg
Mutagenicity Nerative
Skin sensitization   Negative
Repeated-dose study
(three months)
NOAEL 3,610 mg/kg/day
Water flea 4,190 mg/kg/day

NOAEL: No Observed Adverse Effect Level