What is LEM The extract from the cultured solid medium of Lentinus edodes mycelia.Since 1969.
"LEM®” is the extract from solid medium cultured with Lentinus edodes (shiitake) mycelia. The extract has obtained from crushed shiitake mycelia cultured solid medium by physically special technique after the mycelia of shiitake are cultured on solid medium consist of food materials. Main Ingredients are water-soluble lignin (Low-molecular-weight lignin), polysaccharides, proteins and minerals.
The aqueous solution and granule containing LEM® are given permission to manufacture and sell by Japanese authority based on the Food Sanitation Low from 1972. Then these products are selling under a trade name “SHIIKIN”, “JOGEN” as a health food and are having a strong following of users.
These activities of LEM® was not direct action against cancer cells but through host-mediated immunoregulation activity. It was recognized that LEM® induced production of IL-1, IL-2, IL-12, TNF-a, IFN-r and NO in the results of in vitro and in vivo experiments.
Based on these studies, the effects of LEM® against Human Immunodeficiency Virus (HIV, causal agent of acquired immunodeficiency syndrome) had examined. As a result, it was found that LEM® had the ability to inhibit HIV infection to host cells, infection in co-culture system. In addition, LEM® had the ability to inhibit cytopathic effect, reverse transcriptase activity.
Evidence of the power of “LEM”
- Water-soluble lignin -
As it is described above, LEM shows host mediated immunopoteiciation, anti-viral activity and anti-oxidation activity with extremely safety on the test of animals, and with almost no side-effect foe human beings, based on the result of the long period administration clinical test. From all of these clinical studies, it is found LEM, with its long period administration, activates the immunopoteiciality gradually and balances the homeostasis, as well as that LEM is effective health food for viral hepatitis with safety.
Since LEM (registered trademark) is an immune modulator, it is mainly used by people with reduced immunosensitivity. A patient undergoing conventional cancer treatment. For this reason, LEM® is commonly used in clinics and facilities as part of an integrated or complementary approach, along with traditional treatments.
While products containing LEM® are sold all around the world, the raw material used in their production is made nowhere else but our factory.
Safety and reliability of “LEM”
- Safety of LEM -
Shiitake using for manufacturing of LEM has been traditionally used as food. Therefore, it is considered safe for use. In addition, the safety of LEM has been proved on various safety test (e.g. toxicity and mutagenicity tests) by specialized institutions. Based on these results, LEM is considered to be safer than sugar.
|Mutagenicity||Nerative (in Ames test, Rec-assay, and umu-test)|
|Aquatic animals||LC50||Carp||906 mg/kg(96hr)
|Water flea||513 mg/kg(48hr)|